CD34+ Hematopoietic Stem Cells
CD34, a single-pass type I transmembrane
glycoprotein, is typically expressed on
lymphohematopoietic stem and progenitor cells.
CD34+ fractions enriched from human cord
blood are up to 100-fold enriched in various
colony forming units (CFUs), including
CFU-blast, CFU-macrophage, CFU-granulocyte
as well as burst forming-erythroid (BFU-E). In vivo
and in vitro, as these cells mature and
differentiate, the level of CD34 expression on
the cell surface decreases. CD34+ cells are
capable of maintaining long-term hematopoiesis.
Current methodologies utilizing CD34+ enriched
fractions from human cord blood include ex vivo
genetic modification, transplant and engraftment
studies, graft versus host disease studies, drug
resistance gene delivery anticancer vaccination
research, as well as toxicological testing.
glycoprotein, is typically expressed on
lymphohematopoietic stem and progenitor cells.
CD34+ fractions enriched from human cord
blood are up to 100-fold enriched in various
colony forming units (CFUs), including
CFU-blast, CFU-macrophage, CFU-granulocyte
as well as burst forming-erythroid (BFU-E). In vivo
and in vitro, as these cells mature and
differentiate, the level of CD34 expression on
the cell surface decreases. CD34+ cells are
capable of maintaining long-term hematopoiesis.
Current methodologies utilizing CD34+ enriched
fractions from human cord blood include ex vivo
genetic modification, transplant and engraftment
studies, graft versus host disease studies, drug
resistance gene delivery anticancer vaccination
research, as well as toxicological testing.
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CD refers to Cluster of Differentiation
Copyright 2007, Dynacell Life Sciences, LLC.
Copyright 2007, Dynacell Life Sciences, LLC.
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